Yeah..you read that right. There’s actually a plant called insulin plant and it’s supposed to reduce blood glucose levels(no surprise there).You have probably heard of several natural remedies for diabetes and are rolling your eyes now.. The diabetes armamentarium is brimming with antidiabetic agents which are effective and proven. Some like GLP1 analogues and SGLT2 inhibitors have even proven to have cardiovascular benefits.
So why bother about a plant?
For a couple of reasons
- Research : There are many plants which have potential antidiabetic diabetic activity – infact there are at least 111 plants which are known to reduce blood glucose. (1). However the Indian patent laws do not allow patenting plants and more importantly medicines derived from natural products. I have always had trouble understanding the second clause – even if you do some fancy chemical extraction and make a useful substance that was essentially hidden underground for millennia, you wouldn’t get a patent in India. Consequently the incentive to exploit the “natural remedies” for commercial gain is very limited. Thus,most of these plants/plant based substances may never reach the market as a tablet. Does that mean we can’t study them or learn from them? Not really – one can essentially mimic a natural substance, tweak it, call it bioinspiration and pretend that the molecular structure was an epiphany during a coffee break ! Or at least apply for an AYUSH grant to do some research – I’m a novice here, but I guess there can’t a better time to apply for AYUSH grants than now. Even if we aren’t involved in the business of making drugs, if the natural form is safe enough, we can consume them. Even if the effect is modest.
- Clinical: Apart from the research aspect, there is a huge public craze for cost effective natural remedies or drugs derived from plants. The runaway success of products like BGR34 is a testimony to this.
Now you might wonder, if this plant stuff is good, it should have a good scientific backing. Indeed there’s a good body of research behind this. But let’s be frank – research is often locked behind paywalls. Even when it is ‘accessible’ it isn’t truly accessible to those outside the profession – most people are turned off by graphs,tables and statistics. The idea of this post is to simply strip the complexity off the published scientific literature and bring the reader upto speed on this quirky plant.
Here’s a brief bio of the insulin plant in Q&A format
What exactly is the insulin plant?
This plant belongs to the Costaceae family – two species are common , the Costus igneus and the Costus pictus. The leaves of this plant are sometimes taken as supplements for reducing blood sugar. Known as the Spiral flag( insulin chedi in Tamil and Malayalam), the plant can grow upto 2 feet and has colorful flowers.
What does the plant contain?
It contains triterpenoids such as α and β amyrin,lupeol, stigmatsterol.,Diosgenin etc. That’s a lot of active principles- but mostly we are yet to understand how these substances interact with one another and whether isolating them is more useful than the natural mixture in which they are found.
How do I get this plant?
The insulin plant can be obtained from a nursery or someone who is already using it. Care should be taken to avoid mistaking some other plant for this. For the purposes of research, the identity of the plant needs to be confirmed by the Botanical Survey of India,Coimbatore. They give an authentication certificate with a number and date.
Is it safe for human consumption?
Published Toxicity studies in animals show no major toxic effects in the short term (2). Anecdotal human evidence seems to support this. However one should remember that with plants/plant products, there are a lot of variables one must account for – subspecies,soil,part of the plant, extract or whole leaves, growth in shade vs sunlight etc. Since there are no published long term human studies, we are essentially on our own when consuming this. Consequently, those at risk of hypoglycemia (elderly, recurrent hypos, comorbid illness, kidney diseases) and pregnant women should strictly avoid experimenting on themselves.
Is it effective in reducing blood sugar?
Much of the published research on this plant is from animal studies. These animal studies generally show a reduction in blood glucose. You can get a gist of the published research in the form of table by clicking here
Homogeneity is hard to obtain in these studies. Only limited human data is available. The absence of data doesn’t mean absence of useful effect though.
Does it have any other uses?
These days plenty of drugs reduce glucose. It is only natural to expect more !. Plant products tend to have pleiotropic effects and may well have off target effects which we don’t want. There are some of the effects of the insulin plant.
- Hypolipidemic effect
- Antioxidant effect
- Diuretic effect
- Anticancer effect
- Reduces TSH (3)
What does the current research mean?
Very little is known about the insulin plant – especially the human use of it. However, with the public clamor for natural remedies, there may be a future for this plant/its products. Because of its pleiotropic effects, it might have a role in conditions such as prediabetes,subclinical hypothyroidism apart from diabetes.
To conclude, the insulin plant is a potential plant therapy for diabetes. However at present we don’t know much about its human use and thus must proceed with caution.It opens up several research areas. If found useful in raw form, it may become one of the cheapest ways of treating diabetes.
1. Eddouks M, Bidi A, El Bouhali B, Hajji L, Zeggwagh NA. Antidiabetic plants improving insulin sensitivity. J Pharm Pharmacol. 2014 Sep;66(9):1197–214.
2. Hegde PK, Rao HA, Rao PN. A review on Insulin plant (Costus igneus Nak). Pharmacogn Rev. 2014 Jan;8(15):67–72.
3. Ashwini S, Bobby Z, Sridhar MG, Cleetus CC. Insulin Plant (Costus pictus) Extract Restores Thyroid Hormone Levels in Experimental Hypothyroidism. Pharmacognosy Res. 2017 Mar;9(1):51–9.